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Role of lubricin and boundary lubrication in the

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Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Kimberly A. Wallera, Ling X. Zhangb, Khaled A. Elsaidc, Braden C. Fleminga,d,e, Matthew L. Warmanf,g, and Gregory D. Jaya,b,h,1 aCenter for Biomedical Engineering and the ...

The role of lubricin in normal and pathological joint tissue: A contemporary review.OA Anato

The role of lubricin in normal and pathological joint tissue: a contemporary review G Musumeci 1* Authors affiliations (1) ... It has been shown that lubricin is critical to normal joint function, providing boundary lubrication of congruent articular surfaces under ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis | PN

These results demonstrate a direct connection between lubricin, boundary lubrication, and cell survival and suggest that supplementation of synovial fluid with lubricin may be an effective treatment to prevent cartilage deterioration in patients with genetic or ...

Proteoglycan 4 - Wikiped

Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis.When first isolated, cartilage lubricin was called "superficial zone protein" (SZP). Lubricin, MSF, and SZP are now collectively known as Proteoglycan 4 (hence PRG4 for the gene nomenclature).

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

These results demonstrate a direct connection between lubricin, boundary lubrication, and cell survival and suggest that supplementation of synovial fluid with lubricin may be an effective treatment to prevent cartilage deterioration in patients with genetic or ...

Galectin-3 Binds to Lubricin and Reinforces the .

Effective boundary lubrication by lubricin is dependent upon both its ability to adsorb to articular cartilage 11,12 and the presence of O-linked β(1–3)Gal-GalNAc oligosaccharides 13; however ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

These results demonstrate a direct connection between lubricin, boundary lubrication, and cell survival and suggest that supplementation of synovial fluid with lubricin may be an effective treatment to prevent cartilage deterioration in patients ...

Conformational Mechanics, Adsorption, and Normal Force Interactions of Lubricin and Hyaluronic Acid on Model Surfaces - Langmuir (ACS Publication

Glycoproteins, such as lubricin, and hyaluronic acid (HA) play a prominent role in the boundary lubrication mechanism in diarthrodial joints. Although many studies have tried to elucidate the lubrication mechanisms of articular cartilage, the molecular details of how ...

Lubricin: New Promise for Joint-Preserving Therapy | Rheumatology Netwo

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Proc Natl Acad Sci (2013) 110:5852-5857 23. Waller KA, Zhang LX, Fleming BC, Jay GD. Preventing friction-induced chondrocyte apoptosis: comparison of human synovial fluid ...

Boundary mode lubrication of articular cartilage by .

Lubrication of cartilage involves a variety of physical and chemical factors, including lubricin, a synovial glycoprotein that has been shown to be a boundary lubricant. It is unclear how lubricin boundary lubricates a wide range of bearings from tissue to artificial surfaces, and if the mechanism is the same for both soluble and bound lubricin.

Proteoglycan 4 - Wikiped

Function Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis. When first isolated, cartilage lubricin was called "superficial zone protein" (SZP).

Regulation of lubricin for functional cartilage tissue regeneration: a review | Biomaterials Research | Full Te

The fundamental role of lubricin is lubrication of boundary surface of cartilage []. Hence, transmutation of lubricin metabolism would conspicuously influence joint performance. In fact, patients who suffer from osteoarthritis (OA), degenerative joint disease, or ...

Anti-Inflammatory Mechanism of Lubricin/Proteoglycan 4 .

Background/Purpose: Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblast and superficial zone chondrocytes. PRG4 has a multifaceted homeostatic role in the joint including boundary lubrication, friction lowering of apposed cartilage surfaces and prevention of synovial overgrowth.

Supramolecular synergy in the boundary lubrication of synovial joints. — The Kennedy Institute of Rheumatolo

Hyaluronan, lubricin and phospholipids, molecules ubiquitous in synovial joints, such as hips and knees, have separately been invoked as the lubricants responsible for the remarkable lubrication of articular cartilage; but alone, these molecules cannot explain the ...

Regulation of lubricin for functional cartilage tissue regeneration: a revi

The fundamental role of lubricin is lubrication of boundary surface of cartilage [18]. Hence, transmuta-tion of lubricin metabolism would conspicuously influ-ence joint performance. ...

Molecular Aspects of Boundary Lubrication by Human Lubricin: Effect of Disulfide Bonds and Enzymatic Digestion - Langmuir (ACS Publication

Molecular Aspects of Boundary Lubrication by Human Lubricin: Effect of Disulfide Bonds and Enzymatic Digestion† ADVERTISEMENT Log In ...

Lubricin | definition of lubricin by Medical dictiona

Because of that, in the last decade there has been a revived interest in the role of boundary lubricants such as phospholipids, lubricin, ... lubrication lubricin Luc luc-Luc, Henri Lucas Lucas sign Lucas, Richard C. Lucas-Championnière disease Lucatello sign ...

Superficial Zone Protein (Lubricin) in the Different Tissue Compartments of the Knee Joint: Modulation by Transforming Growth Factor Beta 1 and .

Abstract Superficial-zone protein (SZP), also known as lubricin, is a key mediator of boundary lubrication and plays an important role in the functional integrity of the diarthrodial joint. The aim of this investigation was to examine the role of transforming growth factor ...

The role of lubricin in normal and pathological joint tissue: a contemporary revi

boundary lubrication of congruent articular surfaces under conditions of high contact pressure and near-zero sliding speed. ... The role of lubricin in normal and pathological joint tissue: a contemporary review. OA Anatomy 2013 Feb 01;1(1):2. rod and, in solution ...

The role of lubricin in normal and pathological joint tissue: a contemporary revi

boundary lubrication of congruent articular surfaces under conditions of high contact pressure and near-zero sliding speed. ... The role of lubricin in normal and pathological joint tissue: a contemporary review. OA Anatomy 2013 Feb 01;1(1):2. rod and, in solution ...